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Assessment of the effects of three phytochemicals on the white blood cell count

Denial Smith

Nigella Sativa (NS), Thymoquinone (TQ), and Epigallocatechin-3-Gallate (EGCG) are phytochemicals that might have antioxidant protective potentials on the hamster cheek pouch epithelium (HCPE). We aimed at evaluating and comparing the potential therapeutic outcomes of these 3 phytochemicals by analysis of peripheral White Blood Cell (WBCs) counts. NS whole oil, TQ, and EGCG were administered before, with, or after 7,12-Dimethylbenza[A]Anthracene (DMBA) painting the hamster's left cheek pouch. Before sacrificing each animal, 2 ml of blood was withdrawn into a fine heparin-containing tube to estimate the total WBCs, lymphocytes, MID cells, and granulocytes counts by an  automatic count system. All cheek pouches were surgically excised and examined with a light microscope. The three phytochemicals showed different levels of protection against DMBA carcinogenic activity, more specifically, TQ and NS had higher therapeutic potential and might be used for treatment and/or preventive management of oral cancer in the future. However, further investigations are required to address the mechanism of action and feasibility of the clinical application of each phytochemical. 


 
Publicação de revisão por pares para associações, sociedades e universidades pulsus-health-tech
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