The Coronavirus Disease-2019 (COVID-19) produced by the Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) is putting the world’s health and economic systems in jeopardy. COVID-19 can produce a wide range of symptoms in certain people, affecting several organs including the lungs, heart, intestines, kidneys, and brain, resulting in multi organ failure, sepsis, and death. These consequences are linked to direct viral infection of these organs, immunological dysregulation, hyper coagulation, and the possibility of developing cytokine storm syndrome. Because COVID-19 is a new virus, the long-term repercussions on the health of recovered individuals are unclear. We focused on current evidence of coronavirus-mediated DNA damage pathways in this study. The evidence suggests that these viruses can cause DNA damage, genomic instability, and cell cycle disruption during replication in mammalian cells. Because the generation of DNA damage and abnormal DNA repair pathways is linked to the development of chronic illnesses such as cancer, diabetes, neurological disorders, and atherosclerosis, it will be critical to investigate comparable effects and outcomes in recovered COVID-19 patients.
