A kidney biopsy is a procedure to remove small piece of kidney tissue that can be examined under a microscope for signs of damage or disease. Kidney biopsy also called as renal biopsy to diagnose a suspected kidney problem. The biopsy sample is taken in two ways: Percutaneous (through the skin) biopsy: a needle placed through the skin that lies over kidney and guided to the right place in the kidney, usually with help of the ultrasound. Open biopsy: the sample of kidney is taken by directly from the kidney during surgery. Then the kidney sample is sent to a pathology lab to check for any signs of disease. He or she will check for any signs of the disease.