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Mitochondrial dysfunction is the central node in the pathogenesis of renal injury in obstructive jaundice

Guixin Zhang*, Jiayue Liu

In our latest paper, we have reviewed the underlying mechanisms, inducible agents and therapeutic strategies of kidney injury in obstructive jaundice (OJKI) [1]. Abnormal bile metabolism is the key inducement of OJKI. The kidney, as the most energy-demanding organ, requires sufficient energy to eliminate the bile and other waste in blood. About 7% of ATP energy consumption of human body is used by kidney [2]. It is closely related to the abundance of mitochondria in the renal tissue. It is doomed that mitochondria, as an important eukaryotic organelle, are of great significance to maintain the homeostasis of intracellular environment and the life activities of the organism in OJKI.

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