In clinical practice, parenteral formulations are essential and frequently the only way to provide medications that cannot be administered by other channels, such as proteins and some anticancer medications, which are essential to treat some of the most common chronic diseases in the world (like diabetes and cancer). Additionally, because they are the only ones that deliver a drug's immediate action after injection, parenteral formulations are important in emergency care. However, because of the unique quality and safety standards established for these preparations as well as the inherent characteristics of the medications, developing parenteral formulations is a challenging undertaking. One of the most favorable methods for creating parenteral formulates been found to be the production of water-soluble host-guest inclusion complexes with Cyclodextrins (CDs). A number of compounds, especially medicines, can form water-soluble host-guest inclusion complexes with CDs, which increase their apparent water-solubility, chemical stability, and bioavailability and making them appropriate for parenteral administration. Additionally, CDs can be used as the foundation for more sophisticated injectable drug delivery systems with improved properties, like supramolecular hydrogels and nanoparticles, which have been demonstrated to be particularly effective for the administration of anticancer medicines.
