The world is facing a new pandemic due to the SARS-CoV-2 outbreak that began in Wuhan, China in December 2019. The genetic differences of the host and risk factors such as: personal history, lifestyles and environmental factors can contribute to the marked inter-individual clinical variability in COVID-19. Objective: to identify the personal pathological history (comorbidities, infections and smoking) associated with SARS-CoV-2 infection and the clinical course of COVID-19 patients. Method: analytical observational study of cases and controls in Pinar del Río. Personal history of chronic diseases, infections and smoking were explored. Results: personal pathological history of allergy and asthma were risk factors for developing symptoms. A history of dengue infection was associated with SARS-CoV-2 infection and the development of symptoms. A history of pneumonia/bronchopneumonia was associated with the symptomatic course of the disease. The active smoker is shown as a risk factor for infection. Conclusions: it is shown that personal history of chronic diseases, infections and smoking increase the risk of SARS-CoV-2 infection and contribute to the development of symptoms in COVID-19 patients in Pinar del Río.
