The Wnt/β-catenin flagging is a saved pathway that plays a vital part in undeveloped and grown-up life. Dysregulation of the Wnt/β-catenin pathway has been related with infections including disease, and parts of the flagging have been proposed as imaginative remedial targets, essentially for malignant growth treatment. The consideration of the overall specialists paid to this issue is expanding, likewise taking into account the helpful capability of these specialists in sicknesses, like Parkinson's illness (PD), for which no fix is existing today. Much proof demonstrates that unusual Wnt/β-catenin flagging is associated with growth immunology and the focusing of Wnt/β-catenin pathway has been additionally proposed as an alluring technique to potentiate disease immunotherapy. During the last 10 years, a few items, including normally happening dietary specialists as well as a wide assortment of items from plant sources, including curcumin, quercetin, berberin, and ginsenosides, have been distinguished as powerful modulators of the Wnt/β-catenin flagging and have acquired interest as promising contender for the improvement of chemo preventive or restorative medications for malignant growth. In this audit we make an outline of the nature-determined compounds answered to have antitumor movement by adjusting the Wnt/β-catenin flagging, likewise zeroing in on extraction techniques, substance highlights, and bio-action examines utilized for the screening of these mixtures., if not exclusively, taken from the work carried out in the laboratory, although there are numerous other examples in the literature.