The most common genetic kidney disease is autosomal dominant polycystic kidney disease (ADPKD). Cyst development is triggered by a defect in cilia-mediated signaling activity. As a result, ADPKD is considered a systemic disease with many extrarenal consequences, such as cysts in the liver, pancreas, spleen, or ovaries. Loss of function of primary cilia has recently been discovered to have a role in the malignant transformation of degenerated thyroid follicles. thyroid nodules are more common in ADPKD patients, but this hasn't been proven conclusively. The goal of this study was to compare the incidence of thyroid lesions in patients with ADPKD to prior population studies. We also wanted to see if the rate at which the disease progressed was linked to a larger prevalence of thyroid lesions.
